Get a Pregnancy Double Marker test at VRX Diagno Lounge, Goregaon West — measures PAPP-A and Free βhCG in maternal blood. Combined with the NT scan, gives the highest detection rate for Down syndrome (trisomy 21) and trisomy 18 in the first trimester.
The Double Marker Test is a maternal blood test done in the first trimester (10–13+6 weeks). It measures two markers — PAPP-A (Pregnancy-Associated Plasma Protein A) and free β-hCG. Combined with the NT scan, it provides a combined first-trimester risk for Down syndrome (T21), trisomy 18 (T18), and trisomy 13 (T13), with detection rates of about 85–90%.
Low PAPP-A + high free βhCG together with raised NT — highest combined risk
Both markers typically low
Both markers low — severe outcome
Very low PAPP-A is associated with miscarriage and IUGR
Low PAPP-A is also a marker of placental insufficiency risk
Algorithm uses NT + markers + maternal age
Routine first-trimester screen
Higher baseline aneuploidy risk
Strongly recommended in any prior or family case
Routine in assisted-conception cases
Risk calculation differs but still useful
Reassurance with combined screening
Combined risk refines decision-making
Standard component
| Parameter | What It Measures | Reference Range |
|---|---|---|
| PAPP-A | Pregnancy-Associated Plasma Protein A | Multiples of median (MoM) |
| Free β-hCG | Free beta-human chorionic gonadotropin | Multiples of median (MoM) |
| Combined T21 Risk | Down syndrome — based on age + NT + markers | Reported as 1: x |
| Combined T18 Risk | Edwards syndrome | Reported as 1: x |
| Combined T13 Risk | Patau syndrome | Reported as 1: x |
| Risk Cut-Off | Typical screen-positive threshold | 1: 250 (T21), 1: 100 (T18/13) |
Low combined risk (below 1:250 for T21) is reassuring; routine antenatal care continues. Continue routine yearly screening if you have risk factors.
Screen-positive (above 1:250 for T21 or 1:100 for T18/13) prompts genetic counselling and consideration of NIPT, CVS, or amniocentesis for definitive diagnosis. Your physician will correlate with symptoms and history.
Every report is reviewed by an experienced pathologist with clear interpretation and clinical comment.
If further evaluation is needed — NIPT (cell-free DNA), Chorionic Villus Sampling, Amniocentesis, Genetic Counselling, Repeat NT — all available at the Goregaon West centre.
Our Goregaon West centre is on S V Road, easily accessible by train, bus, and auto from all parts of the western suburbs. We provide Double Marker Test and other pathology services to patients from the following nearby areas:
Trained phlebotomist visits with sterile kit at your convenience. Same-day report via email & WhatsApp.
Visit any of our 3 centres for Double Marker Test and other diagnostic services — walk-ins welcome
Practical answers about preparation, ranges, and booking